Phenanthrenes and derivatives
Medchemexpress LLC Vardenafil hydrochloride trihydrate | 330808-88-3 | 99.7% | 200 MG
Vardenafil hydrochloride trihydrate is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5) with an IC50 of 0.7 nM. It shows inhibitory effects towards PDE1 and PDE6 with IC50s of 180 nM and 11 nM, respectively, while IC50s are >1000 nM for PDE3 and PDE4. It competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis, which increases cGMP levels. It can be used for research related to erectile dysfunction, hepatitis, and diabetes.
- It is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5).
- It has an IC50 of 0.7 nM for PDE5.
- It inhibits PDE1 and PDE6 with IC50s of 180 nM and 11 nM.
- It competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis.
- It increases cGMP levels.
- It can be used for the research of erectile dysfunction.
- It can be used for the research of hepatitis.
- It can be used for the research of diabetes.
Medchemexpress LLC Methacycline hydrochloride | 3963-95-9 | 99.3% | 200 MG
Methacycline hydrochloride is a tetracycline antibiotic that inhibits bacterial protein synthesis. It is also a potent epithelial-mesenchymal transition (EMT) inhibitor, blocking EMT in vitro and fibrogenesis in vivo without directly affecting TGF-β1 Smad signaling. This compound is an antimicrobial and has potential for pulmonary fibrosis.
- Inhibits bacterial protein synthesis
- Acts as a potent epithelial-mesenchymal transition (EMT) inhibitor
- Blocks EMT in vitro and fibrogenesis in vivo
- Demonstrates antimicrobial properties
- Shows potential for pulmonary fibrosis treatment
- Inhibits A549 EMT with an IC50 of approximately 5 μM
- Attenuates Bleomycin-induced canonical EMT markers
- Improves survival at Day 17 in vivo studies
Medchemexpress LLC Vardenafil hydrochloride | 224785-91-5 | 99.8% | 200 MG
Vardenafil hydrochloride is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5) with an IC50 of 0.7 nM, showing lower inhibition of PDE1, PDE6, PDE3, and PDE4. It competitively inhibits cGMP hydrolysis, leading to increased cGMP levels. It is used for research of erectile dysfunction, hepatitis, and diabetes.
- Specifically inhibits cGMP hydrolysis by PDE5, increasing intracellular cGMP levels for increased dilation and blood flow.
- Exhibits facilitator effects in rats with cavernous nerve injury.
- Protects the liver against Con A-induced hepatitis in mice and decreases NF-κB expression.
- Prevents reduction of tissue cGMP levels and increased 3-NT generation in ZDF hearts.
Apexbio Technology LLC IM-12 1129669-05-1 200mg
IM-12 (CAS 1129669-05-1) is a small-molecule inhibitor targeting glycogen synthase kinase-3 (GSK-3 ) displaying an IC50 of 53 nM GSK-3 is a serine/threonine kinase involved in neuronal development energy metabolism and Wnt/ -catenin signaling In ReNcell VM cells IM-12 inhibits GSK-3 resulting in increased -catenin accumulation enhanced TCF transcriptional activity and elevated neuronal differentiation markers The compound also extends cell doubling time and suppresses proliferation These properties make IM-12 valuable for investigating GSK-3 signaling in neurobiology cell proliferation and differentiation studies
Medchemexpress LLC SKF 38393 hydrochloride | 62717-42-4 | MFCD00069248 | >98.0% | 291.77 g/mol | C16H18ClNO2 | 200MG
SKF 38393 hydrochloride is the hydrochloride salt of SKF-38393, a selective dopamine D1 receptor agonist with a reported IC50 of approximately 110 nM. Supplied as a research-grade solid analytical standard, it is used for in vitro pharmacology, receptor binding, and analytical assays. Not for human or clinical use.
- Selective D1 receptor agonist, reported IC50 ≈ 110 nM.
- Hydrochloride salt form improves solubility for biological assays.
- Molecular weight 291.77 g/mol.
- Chemical formula C16H18ClNO2.
- Provided as a solid analytical standard suitable for in vitro studies.
- Typical purities reported ≥98% by HPLC from third-party suppliers.
- Not for human or clinical use; for research only.
![eMolecules ChemScene / Triphenylene-23671011-hexathiol / 100mg / 632338653 / CS-0182991 / 0.000 / 100077-38-1 / [null] / 420.650 / C18H12S6](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502475670.JPG-250.jpg)
eMolecules ChemScene / Triphenylene-23671011-hexathiol / 100mg / 632338653 / CS-0182991 / 0.000 / 100077-38-1 / [null] / 420.650 / C18H12S6
ChemScene / Triphenylene-23671011-hexathiol / 100mg / 632338653 / CS-0182991 / 0.000 / 100077-38-1 / [null] / 420.650 / C18H12S6
Apexbio Technology LLC Caffeic acid 331-39-5 200mg
Caffeic acid (CAS 331-39-5) is a naturally occurring hydroxycinnamic acid extracted from plant sources such as Solidago decurrens and large-fruited Chinese hawthorn This small molecule is known for its antioxidant activity primarily through the scavenging of reactive oxygen species and inhibition of lipid peroxidation Caffeic acid has also been reported to modulate various cellular signaling pathways including those related to inflammation and apoptosis Due to its bioactive properties caffeic acid is widely utilized in biomedical research to investigate mechanisms of oxidative stress inflammation and associated cellular events It is soluble in hot water and cold ethanol and should be stored sealed in cool dry conditions
Sigma Aldrich Fine Chemicals Biosciences Aristolochic acid I European Pharmacopoeia (EP) Reference Standard | 313-67-7 | MFCD00004996 |
Aristolochic acid I European Pharmacopoeia (EP) Reference Standard | Mol Wt: 341.27 | 313-67-7 | MFCD00004996 |
Medchemexpress LLC Aristolochic acid A | 313-67-7 | MFCD00004996 | 99.9% | 10 MG
Aristolochic acid A is a nitrophenanthrene carboxylic acid supplied as a high-purity research reagent for biochemical and cell-based studies. It is commonly used to investigate NF-κB and AP-1 signaling pathways and for mechanistic studies of nephrotoxicity and carcinogenesis.
- High purity (99.9%).
- Molecular formula C17H11NO7; molecular weight 341.27 g/mol.
- Typically supplied as a 10 mg quantity suitable for research use.
- Used in studies of NF-κB and AP-1 inhibition and mechanisms of nephrotoxicity and carcinogenicity.
- Handle as a toxic and carcinogenic compound with appropriate safety precautions.
Medchemexpress LLC Aristolochic acid Va | 108779-46-0 | 357.27 | 1 MG
Aristolochic acid Va is a natural compound isolated from *Aristolochia* plants. This high-purity compound is intended for research use only, supporting a wide range of studies in natural product chemistry and biological activity.
- Natural compound isolated from Aristolochia plants.
- Suitable for various research applications.
- High purity for reliable experimental results.
- Available in multiple sizes for research flexibility.
AdipoGen Hypericin
Chemical. CAS 548-04-9. Formula C30H16O8. MW 504.5. Isolated from Hypericum perforatum. One of the principal active constituents of St. Johns Wort Hypericum perforatum. Hypericin is a photosensitive pigment/chromophore with bright red fluorescence emission lambdamax 594nm. Has a high triplet quantum yield and ability to produce considerable amounts of singlet oxygen and other ROS species when photoactivated. Antiviral, anticancer and antidepressant agent. Inactivates enveloped viruses including HIV. This photosensitizing agent has shown to induce apoptosis and necrosis in cancer cells during photodynamic therapy. Selective inhibitor of protein kinase C PKC. Has been shown to inhibit other kinases and targets such as EGFR-PTK, PI3K, CKII, MAPK and insulin receptor IR. Necrosis-avid contrast agent investigated for use in non-invasively targeting necrotic tissues, based on to be defined components in the phospholipid bilayer.